Postdoc in Computational protein design

Introduction

• Are you captivated by the ingenious ways wood frogs and icefish survive extreme cold?
• Do you want to combine computational tools for de novo protein design with experimental studies on your designer proteins?
• Are you passionate about research?
• Do you want to work in a multidisciplinary team?

Job Description

Ice-binding proteins (IBPs) protect against freeze damage in polar regions by keeping the nucleation and growth of ice crystals in check. How this works exactly is not yet known. This is because we currently lack designer ice-binders to unravel and utilize the structure-function relations underlying activity. In this project you will combine computational tools for protein engineering with biochemical and structural biology techniques to bridge this knowledge gap. You will engineer thermostable IBPs de novo targeting IBPs that inhibit ice recrystallization and control nucleation for biomedical applications in e.g. heart and kidney cryopreservation.

Job Requirements

• Motivated researcher, with a PhD in Biophysics, Biological Soft Matter, Biochemistry, or related area.
• Strong qualifications or experience with de novo protein design, protein structure prediction (Rosetta, AlphaFold, …), deep learning, structure elucidation, protein expression, C/C++, python
• Affinity for biophysics and/or soft matter science.
• Experience with microscopy (fluorescence/cryo-TEM/optical) and microfluidics; knowledge of crystallization is preferred.
• Ability to conduct high quality academic research, reflected in demonstratable outputs such as an outstanding PhD thesis and publications in peer-reviewed journals.
• Independent and goal-oriented scientist. A team player who enjoys coaching PhD and Master's students and working in a dynamic, interdisciplinary team.
• A proven ability to manage complex projects to completion on schedule.
• Excellent (written and verbal) proficiency in English, good communication and leadership skills. Note that there is no Dutch language requirement.

Conditions of Employment

A meaningful job in a dynamic and ambitious university, in an interdisciplinary setting and within an international network. You will work on a beautiful, green campus within walking distance of the central train station. In addition, we offer you:

• Full-time employment for 2 years.
• Salary in accordance with the Collective Labour Agreement for Dutch Universities, scale 10 (min. € 4,241 max. € 5,538).
• A year-end bonus of 8.3% and annual vacation pay of 8%.
• High-quality training programs on general skills, didactics and topics related to research and valorization.
• An excellent technical infrastructure, on-campus children's day care and sports facilities.
• Unlimited access to the modern on‑campus TU/e Student Sports Center at an exceptionally affordable rate.
• Partially paid parental leave and an allowance for commuting, working from home and internet costs. 
• A TU/e Postdoc Association that helps you to build a stronger and broader academic and personal network, and offers tailored support, training and workshops.
• A Staff Immigration Team is available for international candidates, as are a tax compensation scheme (the 30% facility) and a compensation for moving expenses.

On our website you can discover even more information about our conditions of employment. Build on your career at TU/e!

About us

We are a leading international university where scientific curiosity meets a hands-on mindset. We work in an open and collaborative way with high-tech industries to tackle complex societal challenges. Our responsible and respectful approach ensures impact — today and in the future. TU/e is home to over 13,000 students and more than 7,000 staff, forming a diverse and vibrant academic community.

Our university is located in Brainport Eindhoven — a world‑leading tech region with more than 7,000 high‑tech companies and strong R&D activity. Known for breakthroughs in AI, photonics, semiconductors and advanced manufacturing, Brainport is a place where technology serves people and society. Learn more about the Brainport region here.

The Department of Chemical Engineering and Chemistry focusses on solving societal challenges in health, sustainable energy and circularity using expertise in molecules, materials and chemical processes. We collaborate with academia and industry to enlarge our chain of knowledge. Our top-notch research is internationally renowned and facilitated by a state-of-the-art research infrastructure. High-quality education and research, strong collaboration, independence of researchers and talent development are our core values.

Information

Do you recognize yourself in this profile and would you like to know more? Please contact the hiring manager Prof. Dr. Ir. Ilja Voets, i.voets@tue.nl or +31 40 247 5303.

Visit our website for more information about the application process. You can also contact Marjolein von Reth, HR advice, m.w.v.reth@tue.nl.

Are you inspired and would like to know more about working at TU/e? Please visit our career page.

Application

We invite you to submit a complete application using the apply-button. The application should include a:

• Cover letter in which you describe your motivation and qualifications for the position.
• Curriculum vitae, including a list of your publications and the contact information of three references. Kindly note that we may reach out to references at any stage of the recruitment process. We recommend notifying your references upon submitting your application.
• List of up to five self-selected ‘best publications’ (co-)authored by you with a brief motivation of your contribution to each of these.

Ensure that you submit all the requested application documents. Please note that incomplete applications may not be considered and could be rejected.

We give priority to complete applications.

We look forward to receiving your application and will screen it as soon as possible. The vacancy will remain open until the position is filled.

Please note

• You can apply online. We will not process applications sent by email and/or post. 
• A pre-employment screening (e.g. knowledge security check) can be part of the selection procedure. For more information on the knowledge security check, please consult the National Knowledge Security Guidelines.
• Please do not contact us for unsolicited services.