PhD in De novo design of ice-binding proteins

Introduction

• Are you interested in (de novo) protein design?
• Are you fascinated by ice-binding proteins and ice crystal growth?
• Are you passionate about research?
• Do you want to work in a multidisciplinary team?

Job Description

Ice-binding proteins (IBPs) protect against freeze damage in polar regions by keeping the nucleation and growth of ice crystals in check. How this works exactly is not yet known. You will engineer IBPs de novo, express, purify, and study these to elucidate the relation between IBP structure and function and explore the application potential of IBPs as cryoprotectants. In this project you will combine computational tools for protein engineering with biochemical and structural biology techniques to engineer thermostable IBPs with tailored activity. Particularly, you will focus on IBPs that inhibit ice recrystallization and control nucleation for biomedical applications in e.g. heart and kidney cryopreservation.

Job Requirements

• A master’s degree (or an equivalent university degree) in Molecular (Life) Sciences, Bionanotechnology, Molecular Biophysics, Molecular Biology, Biomedical Technology, or related discipline.
• A solid background in de novo protein design, protein structure prediction (Rosetta, AlphaFold, …), protein expression, structure elucidation, machine learning, C/C++ and/or Python with an affinity for biophysics and/or soft matter science.
• A research and goal-oriented attitude.
• Experience with microscopy (optical/fluorescence/cryo-TEM) and crystallization is preferred.
• Ability to work independently and enthusiastic about working in a dynamic, interdisciplinary, and international context.
• Motivated to develop your teaching skills and coach students.
• Fluent in spoken and written English (C1 level). Good communication skills.

Conditions of Employment

A meaningful job in a dynamic and ambitious university, in an interdisciplinary setting and within an international network. You will work on a beautiful, green campus within walking distance of the central train station. In addition, we offer you: 

• Full-time employment for four years, with an intermediate assessment after nine months. You will spend a minimum of 10% of your four-year employment on teaching tasks, with a maximum of 15% per year of your employment. 
• Salary and benefits (such as a pension scheme, paid pregnancy and maternity leave, partially paid parental leave) in accordance with the Collective Labour Agreement for Dutch Universities, scale P (min. € 3,059 - max. € 3,881).  
• A year-end bonus of 8.3% and annual vacation pay of 8%. 
• High-quality training programs and other support to grow into a self-aware, autonomous scientific researcher. At TU/e we challenge you to take charge of your own learning process. 
• An excellent technical infrastructure, on-campus children's day care and sports facilities.  
• Unlimited access to the modern on‑campus TU/e Student Sports Center at an exceptionally affordable rate.
• An allowance for commuting, working from home and internet costs. 
• A Staff Immigration Team and a tax compensation scheme (the 30% facility) for international candidates. 

On our website you can discover even more information about our conditions of employment. Build on your career at TU/e!

About us

We are a leading international university where scientific curiosity meets a hands-on mindset. We work in an open and collaborative way with high-tech industries to tackle complex societal challenges. Our responsible and respectful approach ensures impact — today and in the future. TU/e is home to over 13,000 students and more than 7,000 staff, forming a diverse and vibrant academic community.

Our university is located in Brainport Eindhoven — a world‑leading tech region with more than 7,000 high‑tech companies and strong R&D activity. Known for breakthroughs in AI, photonics, semiconductors and advanced manufacturing, Brainport is a place where technology serves people and society. Learn more about the Brainport region here.

The Department of Chemical Engineering and Chemistry focusses on solving societal challenges in health, sustainable energy and circularity using expertise in molecules, materials and chemical processes. We collaborate with academia and industry to enlarge our chain of knowledge. Our top-notch research is internationally renowned and facilitated by a state-of-the-art research infrastructure. High-quality education and research, strong collaboration, independence of researchers and talent development are our core values.

Information

Do you recognize yourself in this profile and would you like to know more? Please contact the hiring manager Prof. Dr. Ir. Ilja Voets, i.voets@tue.nl or +31 40 247 5303.

Visit our website for more information about the application process. You can also contact Marjolein von Reth, HR advice, m.w.v.reth@tue.nl.

Curious to hear more about what it’s like as a PhD candidate at TU/e? Please view the video.

Are you inspired and would like to know more about working at TU/e? Please visit our career page.

Application

We invite you to submit a complete application by using the apply button. The application should include a:

• Cover letter in which you describe your motivation and qualifications for the position.
• Curriculum vitae, with information on education, employment, and research experience including a list of your publications and the contact information of three references. Kindly note that we may reach out to references at any stage of the recruitment process. We recommend notifying your references upon submitting your application.
• A copy of your MSc graduation thesis or internship report.

Ensure that you submit all the requested application documents. We give priority to complete applications.

We look forward to receiving your application and will screen it as soon as possible. The vacancy will remain open until the position is filled.

Please note

• You can apply online. We will not process applications sent by email and/or post. 
• A pre-employment screening (e.g. knowledge security check) can be part of the selection procedure. For more information on the knowledge security check, please consult the National Knowledge Security Guidelines.
• Please do not contact us for unsolicited services.